Preparation and evaluation of apigenin solid dispersions in vitro

Objective To prepare apigenin(AP) solid dispersion and measure its dissolution in vitro.Methods Apigenin solid dispersions were obtain with PVP, PEG4000 and PEG6000 as carriers by coevaporation and melting methods respectively, The dissolution characteristics in vitro were studied in simulated intestinal juice and powder X-ray diffraction were used to determine the status of drug in carriers. Results The dissolution of apigenin was improved significantly by solid dispersions prepared,especially the AP-PVP(m: m=1:9) solid dispersion. The drug was an amorphous state in AP-PVP solid dispersion. Conclusions PVP is a very useful carrier in improving the dissolution of apigenin. It is clear that the enhancement of the dissolution rate of AP from PVP solid dispersion is relative to its amorphous state in PVP.