The effect of endogenous granulocyte colony-stimulating factor on white blood cell of non-small cell lung cancer after chemotherapy

Objective To investigate the relationships between endogenous granulocyte colony-stimulating factor(G-CSF) and white blood cell(WBC) of non-small cell lung cancer(NSCLC). Methods Ninety-four patients with NSCLC were involved in the study.Of these patients,71 were treated with chemotherapy(experiment group) and 23 treated with surgery(control group).Blood samples of the two groups were collected before and on the 6th day after chemotherapy. Results ①In the experiment group,the WBC counts and serum levels of G-CSF after chemotherapy were significantly lower than that before chemotherapy(P0.05).②The basal levels of G-CSF in patients with decreased WBC count was significantly lower than that in patients with normal WBC count or increased WBC count or in the control group(P0.05).③In the experiment group,there were 30 cases with lower WBC count after chemotherapy.In these patients the levels of serum G-CSF were 0.0349 ±0.0279 ng/ml after chemotherapy,significantly lower than that(0.089 ±0.049 ng/ml) before the therapy(P0.05).④There was a significant correlation between WBC counts and endogenous serum G-CSF levels(r = 0.265,P0.05).Conclusion The reduction of WBC count after chemotherapy is associated with the basal levels of G-CSF in patients with NSCLC.The endogenous G-CSF level is positively correlated with WBC count in NSCLC patients.