Effect of Salvia miltiorrhiza Bunge on the Organization Structure of Liver and Kidney in Diabetic Rats Induced by STZ

[Objective] The research aimed to observe the effects of Salvia miltiorrhiza Bunge on the organization structure of liver and kidney in diabetic rats induced by STZ.[Method] Using a diabetes rats model established by streptozotocin injection,the selected SD rats were randomly divided into two groups as diabetes group(n=15)and Salvia miltiorrhiza Bunge treatment group(n=15).Another normal control group(n=20)was set up.5 ml/(kg·d)liquid of Salvia miltiorrhiza Bunge was injected orally and filled stomach in Salvia miltiorrhiza Bunge treatment group,the similar dosage of distilled water was taken orally and filled stomach in diabetes group and the normal control group.The period of experiment was 28 days.At the end of the experiment,histological section of all rats' liver and kidney were made and stained by HE.[Result] Compared with normal control group,liver,liver cells,cord,sinusoids irregular,enlarged liver cells,mildly deformed.Model control group increased glomerular volume,vascular ball expansion,renal cysts smaller vesicles,tubular chamber filled with objects ranging from the amount of protein of renal tubular epithelial cells shedding phenomenon.In Salvia miltiorrhiza Bunge decoction treatment group,rat liver and kidney morphology changed to a less extent,or near normal.[Conclusion] Streptozotocin diabetic rats copied liver and kidney had a certain change in the organizational structure,while Salvia miltiorrhiza Bunge on rat liver and kidney lesions somewhat eased the organizational structure,it can seen that Salvia miltiorrhiza Bunge had a certain therapeutic effect on diabetes.