Mohnarin of 2009:Bacterial distribution and resistance surveillance in Beijing

Objective To get information about bacterial resistance and its epidemic trend for clinical reference in the use of antibacterial agents.Methods All of the bacterial susceptibility results from 11 tertiary care hospitals in Beijing from Jan 1 to Dec 31,2009 were collected by unified protocol and the data were analyzed by software WHONET 5.5.The Disc-diffusion or automatic clinical microbiological system method was used for the bacterial sensitivity.Results A total of 28036 bacterial isolates and their antibacterial susceptibility data were collected,which included 19170(68.4%) Gram-negative bacterial strains and 8866(31.6%) Gram-positive bacterial strains.Pseudomonas aeruginosa,Escherichia coli,Acinetobacter baumannii,Staphylococcus aureus and Klebsiella pneumoniae were the most common isolates.The incidences of meticillin-resistant S.aureus(MRSA) and coagulase negative Staphylococcus(MRSCN) were 55.5% and 66.9%,respectively.No vancomycin resistant Staphylococcus strains were found.There were 0.3% of Enterococcus faecalis and 11.1% of Enterococcus faecium resistant to vancomycin.No linezolid resistant Enterococcus were found.6.9% S.pneumoniae were identified as penicillin resistant S.pneumoniae(PRSP).64.3% of E.coli and 46.6% of K.pneumoniae isolates were the strains producing extended spectrum-β-lactamases(ESBLs).Isolates of Enterobacteriaceae were still highly sensitive to imipenem and meropenem.The average resistance rates was less than 1%.About 30% of P.aeruginosa strains were resistant to the two carbapenems,while the drug resistance rate of A.baumannii was higher than that of P.aeruginosa.Conclusion Bacterial resistance was common and Gram-negative bacterial resistance was still on the rise in Beijing.