Comparison of serum pepsinogen between gastric cancer and duodenal ulcer patients

Objective To compare serum pepsinogen I, II levels between patients with gastric cancer (GC) and patients with duodenal ulcer (DU), and study their relationship with Helicobacter pylori (H.pylori) infection. Method Serum pepsinogen (PG)I, II were tested by TRFIA, and serum H.pylori-IgG was tested by ELISA in both 108 GC and 96 DU patients. Result There was a statistical difference of PGI level between GC and DU, but no difference of serum PGI, PGII level and PGI/PGII was found between H.pylori positive and negative patients with GC and DU. Conclusion PGI level is remarkably lower in GC patients than in DU patients, and H.pylori infection does not influence serum PGI?PGII levels and PGI/PGII in both GC and DU patients.