2007•Journal of clinical and experimental medicineRequires access
Serum pepsinogen and gastric ulcer or gastric cancer.
WU Kang-mei
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Abstract
Objective To discover how serum pepsinogen I(PGI),serum pepsinogen II(PGII) and the PGI/PGII ratio(PGR) change in gastric ulcer and gastric cancer.Methods Serum PGI and PGII of 12 healthy controls and 171 gastric patients were determined by immunoradiometric assay(IRMA).The 171 patients were grouped as: 1.peptic ulcer group: 105 cases;2.gastric cancer group: 66 cases.Results ①Serum levels of PGI and PGII in peptic ulcer patients were obviously higher than those in healthy controls(P0.05),especially in the active stage of the ulcer.There were no differences in serum levels of PGI、PGII between patients in the healing stage of peptic ulcer and healthy controls.②Serum level of PGI and PGR in gastric cancer patients were obviously lower than those in healthy controls(P0.01).There were no differences in serum levels of PGI and PGR between the early stage and the active stage in gastric cancer patients(P0.05).Conclusion The determination of serum PGI、PGII and PGR is helpful for the differentiation of gastric ulcer from gastric cancer.