Relationship of Serum Anti-Helicobacter Pylori IgG titers,Levels of Pepsinogen and Gastric Carcinogenesis

Objective The aim of this study was to explore the distribution of Helicobacter pylori(H.pylori) infection in heath controls and gastric cancer patients and their role of gastric carcinogenesis in Jilin province.Methods From October 2008 to February 2011,a total of 450 pathohistologically confirmed gastric cancer patients hospitalizing for surgical operation at First Hospital of Jilin University and 1 072 healthy controls attending the physical examination center,were included.The serum IgG anti-H.pylori titers and levels of pepsinogen I(PGI) and II(PGII) of the subjects were tested using ELISA kits.Results The rate of positive H.pylori IgG titers was higher in gastric cancer groups than that in healthy control groups(69.5% vs.52.4%,P0.001).The atrophic gastritis was more likely to be diagnosed in gastric cancer groups than those in the control groups(31.4% vs.10.4%,P0.001).More subjects in gastric cancer groups had higher levels of PGII(15.9 vs.11.3,P0.001) and lower ratio of PGI /PGII(5.4 vs.7.8,P0.001) than those in the control groups.In addition,multivariate logistic analysis suggested that H.pylori infection and atrophic gastritis were independent risk factor of gastric cancer.Conclusion The results indicating that the prevalence rate of H.pylori infection was remains high in Jilin province,especially for young patients of gastric cancer.The study also confirmed that both H.pylori infection and atrophic gastritis were linked to the risk of gastric carcinogenesis.Furthermore,compared to PGI,serum PGII concentration and ratio of PGI/PGII potential may become biomarkers for screening of H.pylori-infected gastric disease.