The clinical value of Cystatin C,urea and creatinine in different degree of nephropathy

Objective To evaluated clinical diagnostic values of serum Cystatin C(Cys C),urea(Urea) and creatinine(Scr) in the different degree of kidney damage.Methods Serum Scr was detected by Jaffe rate,serum Urea was measured with UV rate colorimetry and immune turbidimetry analysis used to detect serum Cys C.76 cases with different course of renal dysfunction and 30 healthy controls were collected.Results In normal renal function and mild damage groups,serum Cys C were significantly higher than controls,and serum Urea and Scr were not significantly different(P0.05).Cys C abnormality detection rates of normal renal function and mild damage groups were 43.8%,52.6%,but the Urea and Scr abnormality detection rates were lower.Conclusion Serum Cys C is ideal endogenous marker to reflect changes in GFR,superior to Urea and Scr,and it has an important value in diagnosis and treatment monitoring of varying degrees of renal impairment.