Clinical research of radiosensitization by CMNa on nasopharyngeal carcinoma of stage IVB

OBJECTIVE:To evalution the role of CMNa in enhancing radiosensitivity and its safety on the radiotherapy for nasopharyngeal carcinoma of stage ⅣB.METHODS:A total of 40 patients with nasopharyngeal carcinoma.the lymph of cervix ≥5 cm after 36 Gy irradiation were detected,and 40 patients were randomly divided into CMNa+radiotherapy group(20) and cotrol groups(20).Diagnosis in all cases was confirmed by pathology.The test group were intravenous dripped CMNa 800 mg/m2,with 100 mL NS in 30 min,during treatment period by 3D-CRT in 60 min.Patients in control were only treated with 3D-CRT.RESULTS:The treatment outcome was detected after radiotherapy for 70 Gy.The CR rate in the primary site of test group(95%,19/20) was higher than that of control group(65%,13/20,P=0.02).The CR+PR rate in the lymph of cervix of test group(90%,18/20) was higher than that of group control (55%,11/20,P=0.01).CONCLUSIONS:A positive role for enhancing radiosensitivity of nasopharyngeal carcinoma may be indicated,especially grand lymph in cervix.CMNa combined with radiotherapy is well tolerated.Further study on its sensitizing effect is warranted.