Clinical study of the short-term curative effect of CMNa on nasopharyngeal cancer radiotherapy

Objective To outline the radiation sensitivity efficacy of sodium glycididazole(CMNa)and its toxicity combined with radiotherapy for nasopharyngeal cancer(NPC).Methods Sixty-two patients with NPC were randomly divided into radiotherapy plus CMNa group(group A,n=50)and radiotherapy alone group(group B,n=50).Group A:patients received i.v.CMNa 800mg/m2 within 30 minutes,and 1～3 h after that the patients were given conventional radiotherapy,3 times a week,CMNa was used till the end of radiotherapy,21times for one cycle.Group B:radiotherapy was given by conventional schedule,6MV X-ray conventional irradiation,total dose of the primary site was 68～70Gy every 7 weeks,and the metastatic neck lymph nodes was 64～66Gy every 6.5～7.0 weeks.The partial remission(PR)dosage and complete remission(CR)dosage were calculated,and the side reaction was observed.Results In patients with CR,the sensitization rate(SER)was 1.53。The CR of NPC primary site in groups A and B was 90%(45/50)and 64.0%(32/50)respectively,(P0.05)。The PR and CR dosages of radiation in group A were statistically lower comparing to group B(P0.05).The main toxicities were the reaction of skin and mucous membrane,there was no statistical difference between these two groups.Conclusion CMNa can increase the radiation sensitivity of primary and neck lymph node metastatic site,and improve the short-term efficacy for nasopharyngeal cancer,no side reaction occurred,whether it can reduce the radiotherapy dosage needs further study.