Clinical significance of detection on serum levels of β_2-microglobulin and C-reactive protein in patients with multiple myeloma

Objective To investigate the changes of the serum levels of β2-microglobulin(β2-MG) and C-reactive protein in patients with multiple myeloma(MM) and their clinical implications.Methods The latex-enhanced immunity transmission turbidity method was applied to measure the serum levels of β2-MG and CRP between 60 MM patients and 40 healthy controls and a comparative analysis was performed concerning the alterations in serum varying β2-MG and CRP levels of the varying clinical stages before and after treatment.Results The serum levels of β2-MG and CRP were higher of the MM group than that of the control group,and they increased significantly with the increase of clinical stage,the result was significant different(P0.01).The serum levels of β2-MG and CRP in MM group with effective treatment decreased after treatment compared with those before treatment,the result was significantly different(P0.01),while the result in MM group with effectiveless treatment before and after treatment was not significantly different(P0.05).Conclusion Measurement of serum β2-MG and CRP may be used as an indicator to evaluate the therapeutic effect and prognosis of MM.