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Determination of curcumol and germacrone in Zedoary Turmeric Oil Injections by RP-HPLC

Yu Wang

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Abstract

Purpose To develop a HPLC method for the determination of curcumol and gemacrone in Zedoary Turmeric Oil Injections.Methods The HPLC system consisted of a Agilent TC ODS column(4.6 mm×15 cm,5 μm)and DAD detecter at 210 nm,the flow rate was 1.0 mL/min,and the mobile phase was composed ofmobile phase A:acetonitrile-methanol-water-phosphoric acid(550∶225∶225∶1) and mobile phase B:methanol as gradient mode.Results It shows a good linear range of 0.940 6～94.06 μg/mL(curcumol)and 1.333～133.2 μg/mL(germacrone).The recoveries of curcumol and gemacrone were 100.70% and 100.37% repectively.Conclusion The method is appropriate for the determination of curcumol and gemacrone in Zedoary Turmeric Oil Injections.

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What this paper is about

Purpose To develop a HPLC method for the determination of curcumol and gemacrone in Zedoary Turmeric Oil Injections.Methods The HPLC system consisted of a Agilent TC ODS column(4.6 mm×15 cm,5 μm)and DAD detecter at 210 nm,the flow rate was 1.0 mL/min,and the mobile phase was composed ofmobile phase A:acetonitrile-methanol-water-phosphoric acid(550∶225∶225∶1) and mobile phase B:methanol as gradient mode.Results It shows a good linear range of 0.940 6～94.06 μg/mL(curcumol)and 1.333～133.2 μg/mL(germacrone).The recoveries of curcumol and gemacrone were 100.70% and 100.37% repectively.Conclusion The method is appropriate for the determination of curcumol and gemacrone in Zedoary Turmeric Oil Injections.

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Available abstract

Purpose To develop a HPLC method for the determination of curcumol and gemacrone in Zedoary Turmeric Oil Injections.Methods The HPLC system consisted of a Agilent TC ODS column(4.6 mm×15 cm,5 μm)and DAD detecter at 210 nm,the flow rate was 1.0 mL/min,and the mobile phase was composed ofmobile phase A:acetonitrile-methanol-water-phosphoric acid(550∶225∶225∶1) and mobile phase B:methanol as gradient mode.Results It shows a good linear range of 0.940 6～94.06 μg/mL(curcumol)and 1.333～133.2 μg/mL(germacrone).The recoveries of curcumol and gemacrone were 100.70% and 100.37% repectively.Conclusion The method is appropriate for the determination of curcumol and gemacrone in Zedoary Turmeric Oil Injections.

Key concepts: Chemistry, Chromatography, High-performance liquid chromatography, Methanol, Phosphoric acid, Acetonitrile, Organic chemistry

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