Change of Bone Mineral Density and Bone Metabolism in Elderly Male Type 2 Diabetes Mellitus and Diabetic Nephropathy

Objective: To investigate the bone mineral density (BMD) and bone metabolism in elderly male type 2 diabetes mellitus and diabetic nephropathy. Methods: Dual energy X-ray absorptiometry was used to measure the BMD of lumbar spines and proximal femoral in 131 male 2-DM which were over 60 years old (including 73 cases of normoalbuminuria, 30 cases of microalbuminuria, 28 cases of clinical albuminuria or renal inadequacy) and 49 normal controls. At the same time,was also examined bone metabolism. Results: The decrease of BMD in elderly male patients with 2-DM was related to the prolongation of clinical course. The BMD in group of renal function insufficiency or clinical albuminuria were much lower than that in group of normal control (P 0.05 vs P0.01).The BMD in group of microalbuminuria was also decreased. Conclusion:The BMD in elderly male patients with 2-DM was associated with the course of diabetes and kidney function. The decline of kidney function was an important factor in development of osteoporosis in elderly male patients with 2-DM.