[Change of bone mineral density in type 2 diabetes mellitus with nephropathy].

OBJECTIVE: To investigate into the changes of bone mineral density(BMD) in Type 2 diabetes mellitus with nephropathy(DN) and without nephropathy(DM). METHODS: BMD of lumbar vertebrae 1-4 and femur in 93 cases of Type 2 diabetes mellitus(41 cases of DN and 52 cases of DM) were measured with dual energy x-ray absorptiometry(DEXA) and were compared with age, sex, and BMI-matched normal control group. RESULTS: No significant differences were found in BMD of femoral total, neck, L1-L4 between DM and normal controls in females(P > 0.05). DM in men had higher BDM at L2, femoral total neck than normal controls(P < 0.05). BMD at femoral total, neck, in females and L1-L4 femoral total neck in men in DN group were lower than DM group, but had no statistical differences. CONCLUSION: The changes in BMD of above areas in DM were normal and higher because of different areas. BMD in DN had lower predisposition.