BMD and bone metabolism change in elderly males with type 2 diabetes mellitus and diabetic nephropathy

Objective To investigate bone mineral density (BMD) and bone metabolism in elderly males with type 2 diabetes mellitus and diabetic nephropathy, and analyze the incidence and risk factors of osteoporosis Methods Dual Energy X-ray Absorptiometry(DEXA) was used to measure BMD of the lumbar spine and proximal femora in 70 males with 2-DM who were over 60 years (including 25 cases of normoalbuminuria, 25 cases of microalbuminuria, 20 cases of clinical albuminuria or renal inadequacy). Forty normal controls were also examined at the same time including data of bone metabolism. Results Decreased BMD in elderly male patients with 2-DM was correlated with prolongation of the clinical course. BMD in the group of renal function insufficiency or clinical albuminuria was much lower than that in the normal control group (P0.05 vs P0.01). BMD in the group of microalbuminuria was also decreased. Conclusions BMD in elderly male patients with 2-DM was associated with the course of diabetes and kidney function. Decreased kidney function was an important factor contributing to the occurrence of osteoporosis in elderly male patients with 2-DM.