Correlation between plasma level of B-type natriuretic peptide and cardiac troponin I in patients with coronary disease

Objective To investigate the difference of plasma level of B-type natriuretic peptide (BNP) in patients with coronary disease and correlation between BNP level and plasma cardiac troponin I(cTnI) in patients with acute coronary syndrome (ACS) and to explore the value of BNP in the risk stratification in acute coronary syndrome (ACS). Methods The levels of plasma BNP and cTnI among 78 ACS patients,42 stable angina pectoris (SAP) and 30 without coronary heart disease( CHD) as control were measured by ELISA. The ACS patients were divided into cTnI positive group(48 patients) and cTnI negative group(30 patients). Patients with ACS were followed up for 60 days. The end point was cardiac events including new or recurrent myocardial infraction, new or progressive congestive heart failure, and cardiac death. Results Plasma BNP levels were significantly higher in ACS group (138. 10 ±4. 85)pg/ml than SAP group (30. 62 ± 1. 08)pg/ml and without CHD group (29. 27 ± 1. 45)pg/ml (P 0. 05). There was no significant difference between without CHD group and SAP group in serum BNP levels ( P 0. 05). The level of BNP was significantly higher in ACS patients with cTnl ( + ) group than that with cTnI ( - ) group ( P 0. 05 ). BNP level was positively correlated with cTnI in ACS patients ( r = 0. 57, P 0. 05 ). The plasma level of BNP 80 pg/ml group was correlated with higher rates of new or recurrent MI and new or recurrent CH ( P 0. 05) than that of BNP ≤80 pg/ml group. Conclusion The level of BNP was significantly high and positively correlated with cTnI in ACS patients. BNP has practical significance in evaluating the short-term out-come of ACS. It could be used as a marker for risk stratification of ACS.