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2010•Journal of Tropical MedicineOpen access

The Value of Integrated Detection of Serum High-sensitivity C-reactive Protein,Lipoprotein(a) and Total Cholesterol/High-density Lipoprotein Cholesterol Ratio in Diagnosis of Coronary Heart Disease

Yurong Qiu

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Abstract

Objective To study the value of integrated detection of serum high-sensitivity C-reactive protein(hs-CRP),lipoprotein(a) [Lp(a)] and total cholesterol /high-density lipoprotein cholesterol ratio(TC /HDL) in diagnosis of coronary heart disease(CHD).Method A total of 236 patients with documented CHD and 50 healthy subjects were enrolled in this study for measurement of serum concentrations of hs-CRP,Lp(a)and TC /HDL-C.Results The concentration of hs-CRP,Lp(a) and TC /HDL-C ratio was significantly higher in CHD patients than in the control subjects(P0.01).The sensitivity of integrated detection of all the three markers(94.5%) was higher than the single marker detection of either hs-CRP(85.6%),Lp(a)(82.3%)or TC /HDL(76.2%,P0.05).Conclusion Integrated detection of hs-CRP,Lp(a) and TC /HDL is more accurate and reliable in the diagnosis of CHD.

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Objective To study the value of integrated detection of serum high-sensitivity C-reactive protein(hs-CRP),lipoprotein(a) [Lp(a)] and total cholesterol /high-density lipoprotein cholesterol ratio(TC /HDL) in diagnosis of coronary heart disease(CHD).Method A total of 236 patients with documented CHD and 50 healthy subjects were enrolled in this study for measurement of serum concentrations of hs-CRP,Lp(a)and TC /HDL-C.Results The concentration of hs-CRP,Lp(a) and TC /HDL-C ratio was significantly higher in CHD patients than in the control subjects(P0.01).The sensitivity of integrated detection of all the three markers(94.5%) was higher than the single marker detection of either hs-CRP(85.6%),Lp(a)(82.3%)or TC /HDL(76.2%,P0.05).Conclusion Integrated detection of hs-CRP,Lp(a) and TC /HDL is more accurate and reliable in the diagnosis of CHD.

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Available abstract

Objective To study the value of integrated detection of serum high-sensitivity C-reactive protein(hs-CRP),lipoprotein(a) [Lp(a)] and total cholesterol /high-density lipoprotein cholesterol ratio(TC /HDL) in diagnosis of coronary heart disease(CHD).Method A total of 236 patients with documented CHD and 50 healthy subjects were enrolled in this study for measurement of serum concentrations of hs-CRP,Lp(a)and TC /HDL-C.Results The concentration of hs-CRP,Lp(a) and TC /HDL-C ratio was significantly higher in CHD patients than in the control subjects(P0.01).The sensitivity of integrated detection of all the three markers(94.5%) was higher than the single marker detection of either hs-CRP(85.6%),Lp(a)(82.3%)or TC /HDL(76.2%,P0.05).Conclusion Integrated detection of hs-CRP,Lp(a) and TC /HDL is more accurate and reliable in the diagnosis of CHD.

Key concepts: Internal medicine, Coronary heart disease, Medicine, Lipoprotein, Cholesterol, Total cholesterol, Lipoprotein(a), C-reactive protein

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The Value of Integrated Detection of Serum High-sensitivity C-reactive Protein,Lipoprotein(a) and Total Cholesterol/High-density Lipoprotein Cholesterol Ratio in Diagnosis of Coronary Heart Disease — Research Paper | ScholarLens