2001•Medical Journal of Chinese Civil AdministrationRequires access
The expression of P16 protein and correlation with prognosis of gastric carcinoma.
Lai Danian
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Abstract
Objectives:To study the expression of P16 protein in gastric carcinoma and research the effect and relation with prognosis.Methods:The expression of P16 protein was determined in 60 cases of gastric carcinoma,18 case of benign gastric diseases and 15 cases of normal gastric tissue with immunohistochemical method.Results:The positive rate of P16 protein in gastric carcinoma was lower than that in benign gastric diseases and in normal gastric tissue ( P 0 05).The expression of P16 was closely correlated to tumor histodifferentiation type,degree of differentiation,lymph node metastasis and prognosis of patients with gastric carcinoma.Conclusions:The results suggest that P16 protein may play an important rote in the occurrence and development of the gastric carcinoma.The expression of P16 protein might be a indicator for assessing benign and malignant disease and prognosis of patient with gastric carcinoma.