The Clinical Observation of Benazepril Combined with Rrosiglitazone in Patients with Diabetic Nephropathy

Objective:To evaluate the clinical efficacy of benazepril combined with rosiglitazone in patients with diabetic nephropathy(DN).Methods: 58 patients with stage IV DN were randomLy allocated to a therapeutic group(n=32) or a control group(n=26).Patients in the two groups were given the same regimen,such as common treatment,insulin injection and oral benazepril.The therapeutic group were added with oral rosiglitazone 4 mg daily for 3 months.Before and after treatment,levels of SBP/DBP,Upr,UAE,BUN,Ccr,FG,blood beta2-MG,urine beta2-MG were detected respectively.Results: In both groups,statistically significant differences in levels of SBP,DBP,Upr,UAE,Ccr,urine beta2-MG were observed before and after treatment (P0.05).Post-treatment improvements in these parameters were also recorded in the therapeutic group as compared with controls(P0.05).Conclusion: Benazepril combined with rosiglitazone in treatment of DN showed better effectiveness in reducing albuminuria and improving renal function than benazepril alone,suggesting that combination of the two drugs can be synergistic against DN development.