Clinical effect of high-dose ambroxol in the treatment of severe pneumonia in the elderly

Objective To observe the effect of high-dose ambroxol in the treatment of severe pneumonia in the elderly. Method 51 senior patients with severe pneumonia were selected in intensive care unit( ICU) and divided into the control group and the study group randomly. All of the patients were given conventional treatment. The control group was given intravenously ambroxol with 60 mg,twice per day,while the study group was given large doses of intravenously with 900 mg,one time per day. The treatment lasted 14 d. The clinical pulmonary infection score( CPIS) and inflammatory indicators,arterial blood gas,hepatic and renal function were detected to compare between the two groups. Results After the treatment,the CPIS and the inflammatory indicators of study group were significantly decreased than those of the control group,the difference was statistically significant( P 0. 05). The indexes of blood oxygen pressure and oxygenation were obviously higher in the study group than in the control,the difference was statistically significant( P 0. 05),the mortality rate of study were remarkably reduced compared with the control group,the difference was statistically significant( P 0. 05). While the hepatic and renal function had no significantly difference between the two groups( P 0. 05). Conclusion High-dose ambroxol is efficient and safe for severe pneumonias in eldly patients.