Relationship between HCCR m RNA and primary hepatocellular carcinoma

Objective To detect the expression level of HCCR m RNA in primary hepatocellular carcinoma(PHC) and explore its clinical significance. Methods Reverse transcription polymerase chain reaction was used to detect the expression of HCCR m RNA in PHC tissues, surrounding non-tumor tissues, hepatocirrhosis tissues and peripheral blood mononuclear cells. Results The relative expression level of HCCR m RNA in PHC tissues was 0.83±0.10, and which in surrounding non-tumor tissues and the hepatocirrhosis tissues were 0.12±0.07 and 0.57±0.12, respectively. The differences in the three groups had statistical significance(P0.05). The relative m RNA level of HCCR in the PBMC of PHC patients were 0.55±0.06 and which in the hepatocirrhosis patients were 0.34±0.04, while HCCR expression in the normal ones could not detected. The differences had statistical significance(P0.05). Conclusion The m RNA levels of HCCR in PHC tissues, hepatocirrhosis tissues and their PBMC are up-regulated significantly, which suggests that HCCR maybe involved in the occurrence and development of PHC, and maybe related to the malignant change of PHC.