Polymorphism of Lipoprotein Lipase in Han patients with diabetic coronary heart disease in Zhengzhou

Objective To investigate the effect of Lipoprotein lipase(LPL) in the development of diabetic coronary heart disease(CHD).Methods Polymorphism in intron 6 Pvu II and intron 8 Hind III of LPL gene,serum levels of triglyceride (TG),total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-c) were determined in healthy subjects,patients with diabetes and patients with diabetic CHD.Results The frequencies of P+ and H+,the ratios of genotype in LPL gene showed no difference among all the three groups.There were much higher in TG,TC and LDL-c in genotype P+/P+patients with diabetes or diabetic CHD than non-P+/P+ and healthy subjects,and HDL-c were significantly lower in P+/P+ patiens.Conclusion the mutation of Pvu II in LPL gene may play a role in hyperlipaemia in diabetes or diabetic CAD,so we hope it will be helpful to express the condition of hyperlipaemia in diabetes.