2008•Unpublished venueRequires access

The progress of multidrug resistance-associated protein 2 (MRP2) and its role in cancer drug resistance

DU Fang-bing

Abstract

Multidrug resistance(MDR) play a critical role in the resistance of tumors to multiple anticancer agents.MDR mainly results from overexpression of P-glycoprotein (Pgp),multidrug resistance-associated protein (MRP),lung resistance protein (LRP) and breast cancer resistance protein.MRPs include MRP1-MRP9.The multidrug resistance protein 2 (MRP2) is an ATP binding cassette transporter .Gene characteristic of MRP2 and its role in cancer and chemotherapy is reviewed.

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Key concepts: Multidrug resistance-associated protein 2, Multiple drug resistance, Multidrug Resistance-Associated Proteins, Abcg2, Drug resistance, P-glycoprotein, ATP-binding cassette transporter, Cancer research