Multidrug resistance associated protein 7 and its inhibitors

Mechanism of reversing multidrug resistance (MDR) is associated with transport proteins.Up to date, researches mainly concern P-glycoprotein (P-gp) multidrug resistance associated protein 1(MRP1), breast cancer resistance protein (BCRP) inhibitors. Multidrug resistance associated protein 7(MRP7) is one of ABC transporters ,which belongs to multidrug resistance associated protein (MRP) subfamily. A certain number of studies have been conducted in recent years about it , however , they are relatively less than studies on P-GP,MRP1 and BCRP, et al. Structure of MRP7 has certain differences compared with that of other MRPs,and MRP7 mediates drug resistance to paclitaxel,vincristine,taxanes,etc. In recent years reported inhibitors include cepharanthine tyrosine kinase inhibitors、cyclosporine A,et al. MDR results from a variety of mechanisms so that researches on other transporters may provide extensive ways to reverse MDR. Key words: Drug resistance,neoplasm; Multidrug resistance associated proteins; Multidrug resistance associated protein 7 inhibitors