Effects of percutaneous coronary intervention on plasma N-terminal pro-B-type natriuretic peptide level and clinical significance in the patients with acute myocardial infarction

Objective To study the relationship of N-terminal pro-B-type natriuretic peptide(NT-proBNP) levels in the patients with acute myocardial infarction (AMI) after percutaneous coronary intervention(PCI) with the change of ST-segment, cardiac function and prognosis. Methods The study group included 106 patients with AMI received emergency PCI and the following parameters were measured including the level of NT-proBNP during the PCI,72 hours after PCI and during the follow-up survey after 6 months, the degree of ST-segment resolution, TMP grading of myocardial perfusion, cardiac ejection fraction, main adverse cardiac events (MACE) in 6 months. Results In the group with AMI, NT-proBNP decreased significantly after PCI (P0.05) and also decreased during the follow-up survey after 6 months in comparison to that during PCI and after PCI (P0.01,P0.05). The NT-proBNP decreased remarkably in the patients whose ST-segment resolution was obvious and whose TMP grading of myocardial perfusion was 2~3 grade 72 hours after PCI and during the follow-up survey after 6 months (P0.05). The level of NT-proBNP in the MACE group was higher than that in the non-MACE group 72 hours after PCI and during the follow-up survey after 6 months. Conclusion The level of NT-proBNP of the patients with AMI decreased significantly after PCI. The level of NT-proBNP correlated with myocardial perfusion and cardiac function which could predict the prognosis of the patients with AMI.