Clinical significance and predictive value of high sensitivity C-reactive protein and N-terminal pro-brain natriuretic peptide in patients with acute myocardial infarction after primary percutaneous coronary

Objective To investigate the clinical significance and predictive value of high- sensitivity C-reactive protein( hs-CRP) and N-terminal pro-brain natriuretic peptide in patients with acute myocardial infarction after primary percutaneous coronary intervention(PCI).Methods A total of 80 AMI patients successfully underwent primary PCI and in whom plasma hs-CRP and NT-proBNP were measured,respectively,24 h,72 h,7 days,30 days and3 months after PCI.Major adverse cardiac events( MACE) were observed during hospitalization and within 3-6 months after PCI.Plasma hs-CRP and NT-proBNP levels as well as incidence of MACE in 76 AMI in medically treated group and 30 healthy controls were also examined during the same period and compared with those in PCI group.Results Short-term plasma NT-proBNP levels in medically treated group were significantly higher than those in PCI group,but plasma hs-CRP levels within 72h-7 days were significantly higher in PCI group compared with those in medicine treatment group.MACE in PCI group was lower than that in medically treated group.Conclusion Both plasma hsCRP and NT- proBNP are good predictors for mortality and MACE incidence in AMI patients treated with PCI or medications.hs- CRP is a short- term prognostic factor for AMI patients treated with primary PCI,whereas NT- proBNP is a long- term prognostic factor for AMI patients.