THE EFFECTS OF PERCUTANEOUS CORONARY INTERVENTION ON LEVEL OF N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE AND PROGNOSIS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Objective To explore the change of N-Terminal Pro-Brain natriuretic peptide(NT-proBNP) value in acute myocardial infarction(AMI) patients after emergent or selective percutaneous coronary intervention(PCI) treatment and its relationship with cardiac function and cardiovascular events. Methods Three groups of AMI patients were selected from July,2009 to December,2010.In group A are patients with elevated ST segment and undergoing emergent PCI treatment within 12 hrs after onset(n=46);in group B are patients undergoing selective PCI treatment during their hospitalization(N=42);in group C are patients of AMI being hospitalized within 24 hrs after onset and without PCI treatment(n=34).The plasma NT-proBNP was measured by electrochemiluminescence and ultrasound electrocardiogram examinations were carried out at different time after MI(myocardial infarction) in these patients.The cardiovascular incidents of Group A,B and C were recorded for the following 6 months. Results The NT-proBNP value examined each time of Group A patients was significantly lower than that of group B and C(p0.05);the NT-proBNP value of Group B 11 days after MI and later was lower than Group C(p0.05).The difference in cardiac function between Group A and B,Group A and C,Group B and C was quite obvious on the 45th day and 6 months later(p0.05);Group differences in cardiac incidents among three groups were statistically significant(p0.05). Conclusion The NT-proBNP value in AMI patients decline obviously after emergent or selective PCI,and may be used as the predictor of cardiac function of patients;both emergent and selective PCI can decline the cardiovascular incidents,but emergent PCI distinctly outweighs selective PCI.