Expression of Pokemon in ovarian cancers and its significance

Objective To investigate the expression and significance of transcription factor Pokemon in ovarian cancer.Methods Immunohistochemical method was used to detect the expression of Pokemon in 30 cases of ovarian cancer and 20 cases of normal ovarian tissues,and the relationship between the Pokemon expression and clinical stages and degree of differentiation in ovarian cancer was analyzed.Protein immunoblotting(Western blot) was used to detect the expression of Pokemon in 10 cases of ovarian cancer and 10 cases of normal ovarian tissue.Results With immunohistochemical methods,the expression of Pokemon was positive in 52.63%(19/30) of the ovarian cancer tissues,and in 10%(2/20) of normal ovarian tissues(P0.05).There was no significant difference of positive Pokemon expression in different clinical stages of ovarian cancer tissues,and no significant difference was found in different histological grade groups(P0.05).However,the tendency of higher expression rate was recorded with the poorer grading.With Western blot analysis,strong positive expression of Pokemon was found in 9 of 10 cases of ovarian cancer tissues while in only 1 of 10 cases of normal tissues strong positive expression of Pokemon was found,which was significantly different.Conclusion Pokemon is highly expressed in ovarian cancer tissues.