Expression and clinical significance of Pokemon and mdm2 proteins in breast cancer

Objective To discuss the clinical significance of POK erythroid myeloid ontogenic factor(Pokemon) and mdm2 expressions in breast cancer.Methods The Pokemon and mdm2 proteins in 54 breast tumor tissues and 18 normal breast tissues were detected by immunohistochemistry.The relationship between the expressions of Pokemon and mdm2 and clinic-pathological features of breast cancer were analyzed.Results In the tissues of breast cancer and normal breast,the positive expression rate of Pokemon protein was 74.1%(40/54) and 16.7%(3/18),respectively;the corresponding data of mdm2 was 81.5%(44/54)and 22.2%(4/18),respectively.To Pokemon and mdm2 expressions,there was a statistically significant difference between the group of breast cancer and normal case(P0.05).In breast cancer tissue,the positive expression rates of Pokemon and mdm2 protein were correlated with metastasis of axillary lymph nodes(P0.05),but were not related with the age,the size of tumor,stage of TNM and life span(P0.05).There was a positive correlation between the expressions of the Pokemon and mdm2(rs=0.588,P0.05).Conclusion The Pokemon and mdm2 proteins may involve in genesis,development and metastasis of breast cancer.The Pokemon may be a target gene of breast cancer therapy.