Expression and Clinical Significance of Pokemon mRNA in Breast Cancer

Objective To investigate the expression and significance of Pokemon mRNA in breast cancer.Methods The expression of Pokemon mRNA was detected by using in-situ hybridization(ISH)in 45 cases of breast cancer,20 cases of adjacent noncancerous breast tissues and 20 cases of mammary gland hyperplasia.The clinical and histopathological records were retrospectively analyzed.Results Pokemon mRNA was located in the plasma of breast cancer cells.The rate of strong positive plasma Pokemon mRNA expression was significantly higher in breast cancer than in adjacent noncancerous breast tissue and mammary gland hyperplasia(P0.05),and the rate of strong positive plasma Pokemon mRNA expression was 71.11%(32/45),30.00%(6/20),20.00%(4/20),respectively;The rate of strong positive plasma pokemon expression was significantly higher in breast cancer with axillary lymph node metastasis(90.00%)than in that without axillary lymph node metastasis(56.00%),P0.05).The histology III gradeThe pokemon mRNA expression was significantly higher in grade Ⅲ(100.00%) than that in grade Ⅰ(P0.05).Conclusion Overexpression of Pokemon mRNA is probably related to the carcinogenesis and axillary lymph node metastasis and histology grade of primary breast cancer.