Drug resistance of methicillin-resistant Staphylococcus aureus

OBJECTIVE To analyze the incidence and resistance of methicillin-resistant Staphylococcus aureus(MRSA)so as to provide evidence for the reasonable clinical use of antibiotics.METHODS The identification and antimicrobial susceptibility testing were performed with Phoenix-100.Statistical analysis was carried out with WHONET 5.5and SPSS17.0.RESULTS Totally 314strains of Staphylococcus aureus were isolated,including 164(52.2%)MRSA and 150(47.8%)methicillin-sensitive S.aureus(MSSA);sputum was the highest in the distribution of 58.3%,the next was secretion,accounting for 29.3%;MRSA and MSSA were highly susceptible to glycopeptides and linezolid.The drug resistant rates of MRSA to amikacin,gentamicin,tobramycin,rifampicin,ciprofloxacin,sulfamethoxazole-trimethoprim,clindamycin,erythromycin,tetracycline were 86.6%,89.6%,93.3%,43.3%,87.8%,6.7%,84.1%,84.1%,and 85.3%respectively.The drug resistant rates of MSSA to penicillin,amikacin,gentamicin,tobramycin,rifampicin,ciprofloxacin,sulfamethoxazole-trimethoprim,clindamycin,erythromycin,tetracycline were 92.0%,0.7%,32.7%,32.7%,2.7%,10.0%,34.7%,36.0%,59.3%,and 22.0%,respectively.The drug resistance rates of MRSA strains to macrolides,aminoglycosides,quinolones,tetracyclines,and clindamycin were significantly higher than that of MSSA.CONCLUSION The isolation rate of the MRSA is high,and the strains are highly drug resistant,which should attach great importance to.It is necessary to reasonably use antibiotics based on the result of drug susceptibility testing.