Antibiotics Resistance of Staphylococcus Aureus

[Objective]To investigate the antibiotics resistance of clinical isolates of Staphylococcus aureus,and provide evidence for rational use of antibiotics.[Methods]From January 2007 to May 2009,643 consecutive and non-duplicate Staphylococcus aureus isolates were collected from Wuxi Second people's Hospital.The identification and susceptibility test of the isolate were determined by automated microbiology analyzer.K-B method was used for antibiotics resistance of teicoplanin.[Results]The prevalence of methicillin-resistant Staphylococcus aureus(MRSA) was 71.7% of total isolates.All isolates were susceptible to Teicoplanin,Vancomycin,Nitrofurantion,and Linezolid.The antibiotics resistance of MRSA was significantly higher than that of Methicillin-sensitive Staphylococcus aureus(MSSA).The resistant rate of MRSA toβ-lactam antibiotics,erythromycin,tetracycline,imipenem,clindamycin,gentamicin,levofloxacin and other antibiotics was 82.6%~100%,92.7%,74.8%,92.0%,74.5%,90.5%,78.6%,10%,respectively that indicated MRSA strains were serious multi-drug resistant.The resistant rate of MSSA to penicillin,clindamycin and erythromycin reached up to 93.0%,45.6% and 45.6%,respectively;but to other antibiotics,the resistant rate was down to 0~23%.[Conclusion]MSSA keeps fairly good sensibility to most antibacterial medicine.Compare to MSSA,MRSA has higher antibiotic resistant rate and more serious drug-resistance.Therefore,surveillance on Staphylococcus aureus should be strengthened to reduce the occurrence of its resistance maximally.