Distribution and drug resistance of clinical isolates of gram-positive cocci

OBJECTIVE To understand the distribution and drug resistance of the gram-positive cocci causing nosocomial infections so as to provide basis for the reasonable use of antibiotics.METHODS The bacterial identification and drug susceptibility testing of the gram-positive cocci causing nosocomial infections during 2009-2011 were performed according to the clinical laboratory procedures.RESULTS Of totally 1741 strains of gram-positive/cocci isolated,Staphylococcus aureus,coagulase-negative Staphylococcus(CNS),and Enterococci accounted for 42.96%,31.59%,and 23.21%,respectively.67.5% of the S.aureus strains and 48.0% of the CNS strains were isolated from the lower respiratory tract specimens,72.0% of Enterococci strains were isolated from the urinary tract specimens.S.aureus and the CNS were highly resistant to gentamycin and penicillin,the drug resistance rate to teicoplanin was low,and the drug susceptibility rates to vancomycin and linezolid were 100.0%;Enterocci strains were highly resistant to penicillin and gentamycin,and the drug susceptibility rate to linezolid was 100.0%.CONCLUSION S.aureus,CNS,and Enterococci rank the first three places of the gram-positive cocci,the high drug resistance rate is related to the clinical selection,which has great significance in the guidance of clinical medication.