Clinical distribution and drug resistance of gram-positive cocci causing nosocomial infections

OBJECTIVE To explore the distribution and drug resistance rates of the gram-positive cocci causing nosocomial infections so as to provide guidance for reasonable clinical use of antibiotics and reduction of incidence of nosocomial infections.METHODS From May 2008to Oct 2012,a retrospective survey was conducted to investigate the incidence of infections caused by the gram-positive cocci,then the drug resistance of 246strains of gram-positive cocci was analyzed,and the results of culture were statistically analyzed with the use of WHONET5.4software.RESULTS Of the 246strains of gram-positive cocci isolated from the specimens of the patients with infections,95(38.6%)strains were isolated from the pus specimens,56(22.8%)strains from the wound secretions specimens,43(17.5%)strains from the puncture fluid specimens.Among the 246strains of isolated gram-positive cocci,there were 158(64.2%)strains of Staphylococcus aureus,61(24.8%)strains of coagulase-negative Staphylococcus,and 27(11.0%)strains of Enterococcus.The drug resistance rates of the gram-positive cocci to penicillin,clindamycin,and erythromycin were more than 60.0%,and the strains varied in the drug resistance to other antibiotics and were highly susceptible to vancomycin and teicoplanin.Totally 122strains of methicillinresistant S.aureus(MRSA)and 40strains of methicillin-resistant coagulase-negative Staphylococcus(MRCNS)have been isolated with the isolation rates of 77.2% and 65.6%,respectively.CONCLUSIONIt is necessary for the clinicians to reasonably use antibiotics according to the result of bacteriological examination for the patients and take effective measures for prevention and control of the gram-positive cocci infections.