Analysis of the clinical distribution and drug resistance of 1 296 strains of Gram-positive cocci

Objective To investigate the clinical distribution and drug resistance of Gram-positive cocci in order to guide the clinical use of antibiotics.Methods Conventional methods were used for bacterial culture.A fully automated bacteria identification system from Sunshine Bio was used to identify the bacteria and conduct antibiotic susceptibility testing.Results A total of 1 296 strains of Gram-positive cocci were obtained from a variety of specimens from May 2010 to Mar 2012.The top three isolates of Gram-positive cocci were Staphylococcus aureus(19.06%),followed by Enterococcus faecalis(18.67%) and Staphylococcus epidermidis(13.81%).S.aureus and coagulase-negative Staphylococcus spp.had resistance to a sulfamethoxazole compound and penicillin of more than 80.00% and a resistance to linezolid,teicoplanin,and nitrofurantoin of no more than 10%.Vancomycin-resistant(VRE) strains were not found.Enterococcus resistance to linezolid,teicoplanin,and vancomycin was 4.58%,3.77%,and 3.14%,respectively.Of the isolates,40.48% were MRSA and 72.72% were MRS.MRSA was more resistant to antibiotics than MSSA P0.05).Conclusion S.aureus,E.faecalis and S.epidermidis were the main Gram-positive cocci causing hospital infections.The detection and monitoring of drug resistance among clinical pathogens should be enhanced because of the variance in their drug resistance.Drugs should be used rationally in accordance with the results of drug susceptibility testing.