Evaluation of Multi-tumor Markers Protein Chip Diagnostic System in the Diagnosis of Pancreatic Cancer

Objective:To investigate the application of Multi-tumor markers Protein Chip Diagnostic System in the diagnostic of pancreatic cancer.Methods:Using the Multi-tumor markers Protein Chip Diagnostie System to determine and analyze the concentration values of 12 tumor markers(CA199,NSE,CEA,CA242,FER,β-HCG,AFP,f-PSA,PSA,CA125,HGH,CA153) in the serum of 43 patients with pancreatic cancer,54 benign pancreatic disease and 30 normal persons.By analyzing the validity and the diagnostic potency of the Multi-tumor markers Protein Chip Diagnostic System was evaluated.Results:The validity of this system in the diagnosis of the pancreatic cancer with combination of CA199,CA242,and CEA was evaluatid according the following criteria:sensitivity(86.0%),specificity(66.7%),α(33.3%),β(14.0%),positive likelihood ratio(2.58),negative likelihood ratio(0.21),diagnostic index(153%),Youden's index(0.53),and crude accuracy(75.3%);the criteriafor reliability(concordance correlation coefficient) were:CA199(0.846,P0.01),NSE(0.858,P0.01),CEA(0.906,P0.01),CA242(0.864,P0.01),FER(0.913,P0.01),β-HCG(0.881,P0.01),AFP(0.894,P0.01),f-PSA(0.836,P0.01),PSA(0.875,P0.01),CA125(0.866,P0.01),HGH(0.887,P0.01),CA153(0.875,P0.01). Conclusions:The Multi-tumor markers Protein Chip Diagnostle System had valid valve for its clinical appucation in the diagnosis of pancreatic cancer.The sensitivity could be increased with the combination of CA199,CA242,and CEA.