Combined Detection of CA199,CA242 and CEA in the Diagnosis for Pancreatic Cancer: A Meta Analysis

[Purpose] To investigate the value of combined detection of the tumor markers CA199,CA242 and CEA in the diagnosis for pancreatic cancer.[Methods] A computerized literature search was carried out in the databases to collect articles regarding the diagnostic value of combined detection of the cancer markers CA199,CA242 and CEA. Meta-Disc14.0 and Stata10.0 software were used to conduct the meta-analysis.[Results] A total of 11 literatures were obtained in the present study with the unified inclusion and exclusion criteria. By chemiluminescence immunoassay,the results showed that the sensitivity (SE),specificity (SP),area under curve of SROC curve(AUC) of the tumor markers CA242,CA199 and CEA were 0.90(0.85~0.93), 0.78(0.75~0.83),0.9513 respectively in the diagnosis for pancreatic cancer. In contrast,the indices of SE,SP,AUC of the marker CA199 that was detected alone were 0.80(0.75~0.84),0.81 (0.76~ 0.85),0.8824 respectively. The result of the Z test has proven that significant difference between the two methods(Z=2.999,P=0.0027).By protein chip system for multi-tumor markers detection, the indices of SE,SP,AUC of the tumor markers CA242,CA199 and CEA were 0.84 (0.80 ～ 0.88),0.87 (0.82～0.91),0.9293,respectively.In contrast,the indices of SE,SP and AUC of the marker CA199 that was detected alone were 0.78(0.73～0.82),0.86(0.81～0.90),0.8823 respectively. The result of the Z test has proven no significant difference between the two methods (Z= 1.414,P=0.157). [Conclusion]The combined detection of CA199,CA242 and CEA in the clinically auxiliary diagnosis for pancreatic cancer may provide more competent and valuable laboratory proof compared with solitary detection of CA199.