2004•Journal of Clinical Internal MedicineRequires access
Application of multi-tumor markers protein chip diagnosis system in the Pancreatic cancer
XU Shaoyong
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Abstract
Objective To investigate the application of multi-tumor markers protein chip diagnosis system in the Pancreatic cancer.Methods The multi-tumor markers protein chip diagnosis system was used to determine and analyze the concentrations of 12 tumor markers(CA19-9、CA242、CEA、CA15-3、CA125、AFP、PSA、F-PSA、NSE、β-HCG、HGH、Fe) in 30 patients with pancreatic cancer and 30 healthy persons.Results There was at least one kind of tumor markers found elevated in the 27 patients of 30 patients (positive ratio is 90%).There were 3 healthy persons found elevated (positive ratio is 10%).By t-test,3 kinds of tumor markers (CA19-9,CA242,CEA) were significant in statistics and were selected out from 12 tumor markers.Among those tumor markers CA19-9 was the best diagnosis index;its sensitivity and specificity were 80% and 90%,respectively.The sensitivity of the combined assay was 93.3%.Conclusion Application of multi-tumor markers protein chip diagnosis system is helpful for the diagnosis of pancreatic cancer.