2014•Laboratory Medicine and ClinicRequires access
Clinical significance of combined detection of autoantibodies in patients with systemic lupus erythematosus
Zhou We
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Abstract
Objective To explore the clinical significance of combined detection of autoantibodies in patients with systemic lupus erythematosus(SLE).Methods A total of 60 SLE patients,treated in this hospital from Jan.2012 to Jan.2014,were enrolled as SLE group,and 60 healthy subjects were enrolled as control group.Enzyme-linked immunosorbent assay was performed to detect anti-double stranded DNA(dsDNA)antibody,and Western blot was used to detected ant-nucleosome antibody(AnuA)and anti-Sm antibody.Diagnostic performance of single and combined detection of antibodies was compared.Results Positive rates of anti-dsDNA antibody,AnuA,anti-Sm antibody and combined detection of the three antibodies were 93.3%,33.3%,46.7% and 96.7%in SLE group,which were significantly higher than control group(P0.05).Combined detection of the three antibodies were with higher diagnostic performance.Conclusion Combined detection of AnuA,anti-Sm antibody and anti-dsDNA antibody might be helpful to avoid missed diagnosis of SLE.