Protective effect of tomato juice on liver and kidney damage in mice with cadmium poisoning

Objective To study the effects of of tomato juice on promoting cadmium(Cd) excretion and liver and kidney damage induced by Cd in mice.Methods The mice were given Cd and different concentration of tomato juice.After 4 weeks,the Cd levels of liver and kidney,the activity of alanine aminotranferase(ALT) and the content of blood urea-nitrogen(BUN) in serum of the mice were measured.And the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px),the content of malondialdehyde(MDA) in serum,liver and kidney of the mice were also measured.Results Compared with the model group(15.6±0.11,11.2±0.45 μg/g),the Cd levels of liver and kidney were significantly decreased in the low tomato juice group(12.4±0.52,9.3±0.37 μg/g;P0.01).The serum levels of ALT and BUN(204.4±15.2,11.1±2.05 mmol/L) were significantly decreased than those of model group(502.5±21.3,14.5±3.15 mmol/L;P0.01).The contents of MDA in serum,liver and kidney in the low tomato juice group(10.5±1.2,10.7±2.1,11.3±1.2 nmol/mg·prot) were decreased.However,the activities of SOD and GSH-Px increased.The protective effects showed dose-effect trend.Conclusion Tomato juice has protective effect on the damage of liver and kidney induced by Cd in mice,which is related to the increase of antioxidative effect.