EFFECT OF TOMATO JUICE ON ANTIOXIDATIVE ENZYME IN MICE INDUCED BY CD

[Objective]To observe the different effects of tomato juice and lycopene on antioxidation in mice induced by Cd.[Methods]The mice were given Cd,lycopene and different concentration of tomato juice. After 4 weeks,the Cd levels of liver and kidney,the activity of alanine aminotranferase(ALT)and the content of blood urea-nitrogen(BUN)in serum of mice were measured. The activitives of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),the content of malonydiadehyde(MDA)in serum,liver and kidney of mice were also measured.[Results]Compared with the model group,the Cd levels of liver and kidney,the serum level of ALT and BUN,the contents of MDA in serum,liver and kidney in tomato juice group and lycopene group were decreased. However,the activities of SOD and GSH-Px were increased. The protective effects showed dose-effect trend. The effects of low dose group were weaker than those of lycopene group,but there was no difference between the middle dose group and the lycopene group. The effect of high dose group was stronger than those of lycopene group.[Conclusion]Tomato juice has better protective effect on the damage of liver and kidney of mice induced by Cd than that of lycopne group,which was not only related to lycopene but also related to other phytochemicals,which may have synergistical interaction with lycopene.