Evaluation of the Efficacy in Three-dimensional Conformal Radiotherapy with Temozolomide in Treatment of Postoperative Malignant Glioma

Objective To observe the clinical efficacy and side effects of three-dimensional conformal radiotherapy concomitant with temozolomide in the treatment of postoperative malignant glioma in Chinese patients. Methods 20 postoperative patients with pathologically confirmed malignant glioma previously treated with partial resection of the tumor received three dimensional conformal radiotherapy with concomitant and adjuvant temozolomide chemotherapy. Results The overall response rates(CR+PR) were 80%, including six(30%) patients with complete responses and ten(50%) partial responses. Progression-free survival rate was75%(15/20)at 6 months and 50%(10/20) at 1 year respectively. The one-year survival rate was 70%(14/20). Conclusion Three dimensional conformal radiotherapy with temozolomide in the treatment of postoperative malignant gliomas demonstrates good tolerance and achieved fair short-term efficacy.