A clinical study of ziprasidone vs perphenazine in the treatment of childhood patients with first-episode schizophrenia

Objective: To compare ziprasidone and perphenazine in the treatment of children of first-episode schizophrenia clinical efficacy and safety. Methods: 80 cases of childhood schizophrenia were randomly divided into study group and control group, 40 patients in each group, study group received ziprasidone treatment, control group was given perphenazine treatment were observed for 8 weeks. Before and after treatment in the treatment of 2,4,6,8 weekend to positive and negative syndrome scale (PANSS) to assess the clinical scale with side effects (TESS) evaluation of safety. Results: PANSS total score after treatment compared with before treatment difference was statistically significant (P0.01), but with rapid onset of ziprasidone. The total effective rate was 87.5% of ziprasidone, perphenazine, 80.0%, group no significant difference between (P0.05). Ziprasidone side effects compared with perphenazine. Conclusion: Ziprasidone treatment of children with good effect of first-episode schizophrenia and safe.