Study on inhibition effect of recombinant human lactoferrin in vitro on human ovary carcinoma cell lines proliferation

Objective:To explore the effect of lactoferrin on proliferation of the cultured SKOV3 cells in vitro.Methods:To cultivate SKOV3,HO-8910,HO-8910PM cells in vitro.. MTT assay were used to evaluate the growth inhibition effect of lactoferrin on SKOV3.Results:Lactoferrin significantly inhibited the proliferation of three cells in a dose-dependent manner,the inhibitor rate of SKOV3 was 40.95%,62.03%,72.63% in different concentration,respectively,but had no obvious inhibition on the control cells.Conclusion:Lactoferrin can effectively inhibit the proliferation of Ovary cancer cells,and lay a foundation for exploitation of a new chemistry agent.