Effects of mifepristone on expressions of ER,PR,bcl-2 and bax in endometrium and hysteromyoma

Objective To study the effects of mifepristone on endometrium after treatment of hysteromyoma with mifepristone.Methods The expressions of ER,PR,bcl-2,and bax in both endometrium and hysteromyoma in control group(n=20),and treatment group(n=30)were detected by immunohistochemical S-P method.Results After mifepristone treatment of hysteromyoma,the positive rates of PR expressions in hysteromyoma and endometrium in treatment group decreased(P0.05),whereas the positive rates of ER expressions in hysteromyoma and endometrium in treatment group were not different from those in control group(P0.05).The positive rate of bcl-2 expression in edometrium in mifepristone group was fower than in control group with statistically significant difference.Whereas there was no significant difference in hysteromyoma between the two groups before and after mifepristone treatment.Compared with control group,the positive rate of bax expression in hysteromyoma increased in mifepristone group(P0.05),but it did not differ in endometrium between the two groups(P0.05).83.3%(25/30)of patients in mifepristone group showed changes of proliferative phase in the endomefrium;among them,32%(8/25)showed simple hyperplasia.Conclusions Mifepristone promotes apoptosis of hysteromyoma cells,and probably contributes to proliferation of endometrium.