Effects of mifepristone on cell proliferation,cell invasion and cell apoptosis in tissues of uterine leiomyoma

Objective To investigate the effects of mifepristone on expression of Ki67,MMP2 and Fas in tissues ofuterine leiomyoma and endometrium. Method The 62 cases of uterine myoma patients were randomly divided into the controlgroup(24 cases) and the treatment group(38 cases),patients in the treatment group were treated with mifepristone 25 mg dailyby oral administration for a month beginning on the second to the third day of menstrual cycle. The patients in control groupwere operated directly. Protein expression levels of Ki67,MMP2 and Fas were detected by immunohistochemical technology.Results The positive expressions of Fas in uterine leiomyoma caese were higher in treatment group(55.3%) than the controlgroup(29.2%)(P0.05). The Ki67 expressions of hysteromyoma cases in treatment group(36.8%) were lower than that of thecontrol group(70.8%)(P0.01). The expressions of MMP2 in hysteromyoma cases in treatment group(36.8%) were lower thanthat of the control group(66.7%)(P0.05). However,the difference of expression of Ki67,MMP2,Fas in endometrium betweenthe treatment group and the control group were not statistically significant(P0.05). Conclusion Mifepristone may offer aneffective treatment option for women with uterine leiomyoma by inhibiting the proliferation and invasion,promoting theapoptosis of fibroid cells,in uterine leiomyoma smooth muscle. This may be the mechanism of mifepristone in the treatment of hysteromyoma.