Impact of atorvastatin to inflammatory cytokins' level at acute coronary syndrome patients who received percutaneous coronary intervention

Objective To explore the impact of loading dose atorvastatin to the inflammatory cytokins' level in the acute coronary syndrome(ACS) patients who received percutaneous coronary intervention. Methods Sixty-four ACS patients were divided into two groups,normal atorvastatin dose group and atorvastatin loading dose group. The patients of normal dose group received atorvastatin 10 mg before PCI and subsequently 10 mg/d; the loading dose group received atorvastatin 80 mg before PCI and subsequently 80 mg/d for three days,then changed to 10 mg/d. The concentrations of high sensitive C reactive protein(hs-CRP),interleukin 6(IL-6),plasminogen activator inhibitor 1(PAI-1) P-selectin were detected before PCI and on the 3d,7th 14th day after PCI. Results At the 14th day, the cytokins' concentrations of atorvastatin loading dose group were significantly lower than those normal dose groups respectively hs-CRP ( 3.37± 0.12) mg/L vs ( 5.54± 0.10) mg/L,IL-6( 2.96± 0.18) ng/L vs ( 5.28± 0.24) ng/L and PAI-1( 6.57± 0.24) ng/L vs ( 7.33± 0.57) ng/L(all P 0.05). The loading dose of atorvastatin can not greatly affect the level of blood fat. Conclusion The loading dose of atorvastatin can greatly repress the inflammatory reaction after PCI,thus greatly lowering the concentrations of hs-CRP,IL-6,PAI-1 and P-selectin.