Discussion clinical significance of epidermal growth factor and leptin detection in gastric carcinoma diagnosis

Objective To explore the relationship between epidermal growth factor(EGF) and leptin levels change with gastric carcinoma development.Methods 150 cases gastric carcinoma patients(gastric carcinoma group) and 50 cases healthy people(control group) were collected in our hospital from January 2013 to Autumn 2013.levels of EGF,leptin and alphafetoprotein(AFP) were detected by radio immunoassay.All data were analyzed statistically.Results The levels of EGF,leptin and AFP in gastric carcinoma group were all higher than that of control group,and the differences all had statistical significance(Pall 0.05).Linear correlation analysis showed that level of EGF in gastric carcinoma patient had positive correlation with level of AFP(r= 0.291,P 0.05),and the other index had no relationship.Conclusion Gastric carcinoma patients have high levels of EGF and leptin,but these two index are independent of each other.Level of EGF have contribution to diagnosis and prognosis evaluation of gastric carcinoma.