2014•Academic Journal of Chinese PLA Medical SchoolRequires access
Clinical significance of epidermal growth factor and leptin levels changes in the serum in patients with gastric carcinoma and carcinoma of cardia
Liao Ji
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Abstract
Objective To explore the EGF and leptin levels changes and their relationship with AFP level in patients with gastric carcinoma or carcinoma of cardia. Methods Serum from normal control and patients with gastric carcinoma or carcinoma of cardia in our hospital from October 2012 to January 2013 were collected. EGF, leptin, and AFP levels were detected by Radio-immunoassay in serum of 150 gastric carcinoma patients, 50 carcinoma of cardia patients and 50 normal control. Results The levels of EGF, leptin and AFP were significantly higher in serum of gastric carcinoma and carcinoma of gastric cardia patients than in serum of normal control. In serum of gastric carcinoma patients EGF level had direct correlation with AFP level(r=0.291 2, P0.01) by correlation analysis while other markers had no relationship. Conclusion EGF and leptin levels are higher in serum of gastric carcinoma and carcinoma of cardia patients than in serum of normal control, EGF and Leptin have no relationship in patients' serum, but EGF and AFP are significant to diagnose gastric carcinoma.