2014Journal of Practical DermatologyRequires access

Primary cutaneous extranodal NK/T-cell lymphoma: a case report

Zou Yu

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Abstract

To report a case of primary cutaneous extranodal NK/T-cell lymphoma, and the pertinent literature was reviewed. The patient was 42-year-old, female, who suffered from subcutaneous nodules and ecchymosis for 20 days, and recurrent fever for 4 days. Dermatopathology examination showed that there was a widespread infiltration of lymphoid cells; immunohistrochemistry examination results showed that CD3, CD43, CD56, GгB and TIA-1 were positive; Ki-67 LI was about 60% positive; EBER detected by in situ hybridization was positive. The diagnosis was primary cutaneous extranodal NK/T cell lymphoma, which is a high-grade malignancy. The histopathology and immunohistochemistry examination should be carried out as soon as possible so as to get the defi nite diagnosis.

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What this paper is about

To report a case of primary cutaneous extranodal NK/T-cell lymphoma, and the pertinent literature was reviewed. The patient was 42-year-old, female, who suffered from subcutaneous nodules and ecchymosis for 20 days, and recurrent fever for 4 days. Dermatopathology examination showed that there was a widespread infiltration of lymphoid cells; immunohistrochemistry examination results showed that CD3, CD43, CD56, GгB and TIA-1 were positive; Ki-67 LI was about 60% positive; EBER detected by in situ hybridization was positive. The diagnosis was primary cutaneous extranodal NK/T cell lymphoma, which is a high-grade malignancy. The histopathology and immunohistochemistry examination should be carried out as soon as possible so as to get the defi nite diagnosis.

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Available abstract

To report a case of primary cutaneous extranodal NK/T-cell lymphoma, and the pertinent literature was reviewed. The patient was 42-year-old, female, who suffered from subcutaneous nodules and ecchymosis for 20 days, and recurrent fever for 4 days. Dermatopathology examination showed that there was a widespread infiltration of lymphoid cells; immunohistrochemistry examination results showed that CD3, CD43, CD56, GгB and TIA-1 were positive; Ki-67 LI was about 60% positive; EBER detected by in situ hybridization was positive. The diagnosis was primary cutaneous extranodal NK/T cell lymphoma, which is a high-grade malignancy. The histopathology and immunohistochemistry examination should be carried out as soon as possible so as to get the defi nite diagnosis.

Key concepts: Medicine, Dermatopathology, Histopathology, Lymphoma, Malignancy, Atypical Lymphocyte, Ecchymosis, Pathology

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